Heston turns investigator when an eccentric homeless man, an old acquaintance, leaves him a rather unusual task in his will. Daniel receives an unexpected proposal, while Mrs Tembe decides it is time for affirmative action against Sutton Vale and recruits Sid, but will it all go to plan?
When a young carer is accused of murdering an elderly man, Rob and Emma try to seek the truth. But do they trust the carer or the local gossip who is known for making false allegations? Daniel becomes a target when Al and Jimmi see an opportunity for mischief, while Ayesha steps into the lion's den that is Sutton Vale Medical Centre.
Al soon wishes he hadn't got involved when he follows a trail laid out on a patient's phone. Mrs Tembe has to deal with the possibility of losing staff, while Karen returns from holiday to less than good news.
Sid attends a burglary but isn't sure that all is as it seems. Mrs Tembe plays Mr Smail a visit, while Daniel has his first shift as a shopping channel presenter.
When Jimmi sees a beggar clearly ill, he tries to get involved to help. Mrs Tembe and Emma team up to try to get the better of Smail, while Ruhma prepares Shak for university life.
Ruhma is stuck in the middle when two sisters are at odds over an imminent birth. Emma and Zara try to catch up on work at home, while Valerie tries to persuade Ayesha to read a self-help book.
Rob and Emma have to play detective to identify a young girl brought in for shoplifting. Valerie is tasked with a serious job, while Heston thinks he is being forgotten.
It's the first day of the Minor Surgery Unit, and Heston is very excited. Meanwhile, Ruhma takes Shak off to university, and Karen continues to look for James.
Daniel gets hooked into an interview with a student and ends up going viral for all the wrong reasons. Karen's concern for James continues, and Ayesha finds herself drawn closer to Leo when she gets an insight into what his job means to him.
James tells Karen the heart-breaking story of what life was like for him on the streets. At the station Rob is tasked with finding a homeless man who has gone missing after being attacked while he slept.
Whilst on a VPAS visit, Mrs Tembe discovers the patient is no longer in need of help, but her son is. Karen and James take a step closer to getting a diagnosis, and Valerie helps Shak avoid his mum when he turns up at the campus with an embarrassing issue.
Al feels uncomfortable when he is dragged into a situation with a patient. Karen is keen to get things moving for James, while Zara pushes Emma towards a colleague.
Valerie gets held up at a cafe when a teenage girl's attempt to stand up for herself takes a dangerous turn. Karen faces the consequences of her protest for James. Over dinner Emma and Jimmi wonder if the attraction is still there between them.
Mrs Tembe faces a difficult decision when she meets a war veteran being deceived by his daughter and a charity volunteer. James has a job opportunity, but will he be able to hold his nerve? Elsewhere, Zara and Valerie are both determined to do whatever it takes to win.
Emma is determined her dinner party will be anything but boring, but she soon realises you should be careful what you wish for. Elsewhere, Sid crashes into an unexpected situation and James finally gets some news, but is it what he wanted? Meanwhile Rob decides to take control of his own future.
Ruhma is with a young woman who is having a baby for someone else, but some bad news may be about to change all of that. Sid dives in head first when he thinks he and Keziah might have a romantic future. Elsewhere, Joe's heart sinks when Zara and Daniel go overboard.
Al and Daniel play Cupid with two friends who are concealing their romantic feelings for each other, but will their efforts pay off? Sid has to deal with some sick children who have been exposed to a dangerous chemical. Zara's attempt at bribery proves to be a poisoned chalice.
Rob thinks he knows who is responsible for some children being poisoned by an illegal chemical, but he is thwarted by a fake confession. Sid is at the hospital with the two children who are seriously ill after drinking the poisonous substance. Sid is praised for his quick thinking, but will the boys make it?
Heston helps an unfaithful husband try to win back his wife with a vasectomy, but is it too little too late? Daniel buys Joe a present that ends up being fun for all the family, and Ruhma makes an error that puts a baby at risk.
Jimmi promises a Syrian refugee girl that he will find her sister, but his desire to overstep the mark lands him in hot water. Karen nurses Rob through his 'man flu', and Heston manages to cheer Ruhma up with a trip to a camping shop, just not in the way he was hoping.