In the town of Fairview there's a street called Wisteria Lane; a peaceful cul-de-sac with manicured lawns and beautiful houses. It's a place where you know all your neighbors and your neighbors know all about you. It's the perfect suburban fantasy.But, behind every picket fence there are secrets. And, in every seemingly happy home, you'll find jealousy, lust, passion, and sometimes... murder.
While Bree gives Chuck a ride, a smell becomes noticeable; Gabrielle seeks out a priest in order to help Carlos with his problem; Ben Faulkner, a new neighbor, meets Renee; Susan withdraws from her friends because of what happened to Alejandro.
Gabrielle teaches Carlos how to dance on a strip pole; Susan seeks out a punishment for feeling guilty; Renee bonds with one of the customers at a senior center; Tom and Lynette wonder why Parker was at a late night party; Bree discovers Chuck's past.
Lee has a problem with Jenny; Susan and Carlos attempt to find the people responsible for tagging the wall with graffiti; Lynette grows suspicious of Lydia and her fiancé.
While at a yoga class, Lynette and Renee spy on Jane, Tom's new girlfriend; Gabrielle tries to affect change at a PTA meeting; Bree discovers what Danielle is up to; Susan battles with art class teacher Andre Zeller.
Tom and Lynette visit a couples counselor about their separation; Bree tries to help a city council about the homeless; Carlos is in a guilty situation; Susan is embarrassed about Andre's students being naked in class.
Susan grows suspicious about Amy's affair with Andre; a delivery man tries to deliver a package for Lynette; a man speaks to a sponsor from A.A. about a blackout; the housewives are in the woods with the shovels, but they're being watched.
Bree is stunned when she learns who dug up the body of Gaby's stepfather; jealousy rears its ugly head when Lynette begins to spread untruths to daughter Penny about Tom's new girlfriend; Gaby and Carlos must convince Lee and Bob that Juanita and Celia aren't the bad seeds that they used to be when they want to name them in their will as guardians; and Susan desperately searches her inner self to find what inspires her in order to better her art and impress her hard-to-please art teacher, Andre.
Detective Chuck Vance begins harassing Bree as his suspicions about her involvement in the disappearance of Alejandro grow; after using the murder of Gaby's stepfather as inspiration for her art school projects, Susan must find a way to graciously decline art school teacher Andre's invitation to display and sell her paintings at a gallery showing; when Carlos's drinking gets in the way of his ability to work, Gaby goes to The Office in an effort to save his business from losing a multi-million dollar account; and on the occasion of their 22-year anniversary, Lynette comes up with a plan to try to salvage her marriage to Tom.
Gabrielle, thinking the worst, goes on a frenzied search for Carlos after he unexpectedly checks out of rehab. Meanwhile, a desolate Bree goes on a drinking binge and finds herself in a desperate situation.
Acting on a misconception, Renee discovers just how desperate Bree is feeling, Gaby is concerned that Carlos may have been involved in another murder, and Lynette make a confession to Tom.
While in Oklahoma, Susan learns that the late Alejandro has been sexually abusing his 15 year old step-daughter, Marisa, just like he abused Gabby years earlier. Meanwhile, Bree gets an unpleasant surprise from a man she meets in a bar, Gabrielle tries to bluff her way through a business dinner in order to woo a potential client for Carlos, and Mike catches Ben doing something he shouldn't do to try to salvage his faltering real estate project.
Karen McCluskey finds out about Bree's sex life and interferes, Bree bumps into one of her many conquests unexpectedly, Gabby shares her past with the widow of Alejandro, and after introducing them, Renee ends up paying the price when the date between her hairdresser and Lynette doesn't go well.
Bree's sexual escapades are getting out of hand and help comes from an unexpected source, Susan learns that Julie is pregnant, and Gabby has to deal with a situation at Juanita's school.
Susan discovers the identity of the father of Julie's baby, and Orson makes it his duty to nurse Bree back to health. When Mrs. McCluskey throws Roy out of the house, Gabrielle takes him in and is reluctant to help get them back together when he proves to be an invaluable disciplinarian to her kids. Meanwhile, after getting used to her alone time, Lynette is furious when Porter and Preston are evicted from their apartment and try to move back home, and Mike informs Renee of Ben's dire circumstances with a loan shark.
Susan offers to help the father of Julie's baby raise the child; Bree agrees to go to Maine with Orson - perhaps for good; Karen pleads with Gaby not to tell Roy about her condition; and the loan shark who threatened Ben sets out to ruin Renee.
Susan talks Mike into going to the police when she discovers that Ben's loan shark is out to get him; Mrs. McCluskey, who's dying of cancer, asks Bree to help her commit suicide; Tom's girlfriend, Jane, stuns Lynette at Penny's birthday party; Carlos behaves oddly on his first day back at work, and Gaby is worried.
On the day of a beloved Wisteria Lane resident's funeral, each of the housewives recalls the effect this person had on her life. Meanwhile, Bree is stunned when she's called in for questioning about the murder of Gaby's stepfather, Alejandro.
Bree is not so sure about Andrew's upcoming marriage; Gabrielle tries to find work in an employment agency in order to teach Carlos and the kids a lesson; Lynette plans to win back Tom at any cost; Susan's parenting skills concern Julie; Ben asks Renee to marry him.
Carlos gets concerned about Gabrielle's new job; an affair makes Susan suspicious; the police ask a hotel owner about Alejandro's whereabouts; Bree needs a lawyer's help in order to get her charges of Alejandro Perez's murder cleared. Jane served to Lynette their divorce papers.
With Mike gone, Susan attempts to build a car for MJ’s father-and-son school soapbox derby; Bree’s attorney, Trip, learns of her previous drunken sexual spree and needs her to come clean about it in order to help strengthen her case; Lynette tries to cause some negative friction between Tom and his girlfriend, Jane, by flirting with his boss and getting him to pile more work on her estranged husband; Gaby is furious with Carlos when he tries to poach one of her rich, personal shopper clients and talk her into helping with his newly formed charity organization; and Renee discovers that Ben is keeping a secret from her about his involvement with Bree – and the body found at his work site.
In the penultimate episode leading into the two-hour finale of this landmark series, as her trial nears, Bree begins to fall for her attorney, Trip; Susan becomes concerned when Julie doubts Porter's commitment to be a hands-on father to their unborn baby; as Tom gets closer to being transferred to India for his job - thanks to Lynette - she begins to have second thoughts and tries to convince his boss to rescind the move; and the ladies are shocked about Gaby's nonchalant attitude as Bree continues to stand trial and take the fall for Carlos in the murder of Alejandro.
Five years have passed since Katherine shot her ex-husband as Susan, Lynette, Bree and Gaby stood together in solidarity to protect her. Susan tries to hide her relationship with a new man; Gaby questions her abilities as a mom; Bree is on the verge of publishing her own cookbook as business partner, Katherine, grows envious; Lynette catches her teenaged twins spearheading illegal activities; and Edie returns to Wisteria Lane in jaw-dropping fashion with a new man in tow.
Unaware of Jackson's whereabouts, Susan goes to a local bar suspecting that he might be with Mike however, she soon lands herself in-trouble; meanwhile, after spending money that did not belong to her, Gabrielle attempts to get Carlos to get a job at the local country club as it pays better. Bree promotes her cook book on a radio show.
Bree's estranged daughter, Danielle, returns to Wisteria Lane and is met with a deluge of criticism. Meanwhile, Gabrielle and Susan find themselves embroiled in a catfight brought on by an altercation between their kids. To her chagrin, Lynette comes home to find Tom and Dave have formed a garage band after she told him to get rid of his old things. Finally, Katherine and Mrs. McCluskey invite Edie to lunch to press her for more information on Dave.
Bree's new found success causes the rest of the women on Wisteria Lane to feel envious. Lynette longs to return to her days as an ad-executive, and finds an outlet as Bree's marketing manager. Mike feels that he is not a big enough presence in his son's life after M.J. draws a family portrait and leaves him out. Meanwhile, Gaby comes up with a way to have more sex with Carlos.
Driven by a hidden agenda, Dave convinces Susan to throw Mrs. McCluskey a surprise party for her 70th birthday. Jackson wants to take his relationship with Susan to the next level. Gabrielle's concerned she might be pregnant. Tom tells Lynette he's sold the pizzeria. A startling reason for the bond between Bree and Katherine is revealed. And finally, an outraged Mrs. McCluskey has the entire neighborhood questioning her sanity.
Gaby is over the moon when Carlos' client makes them an offer they can't refuse, but a startling discovery leaves her second guessing. Lynette grows suspicious that Tom is cheating on her. After breaking up with Jackson, Susan tries to surprise him, only to find the surprise is on her. Meanwhile, the bond between Bree and Katherine grows. Finally, Mrs. McCluskey enlists the help of her sister Roberta (guest star Lily Tomlin) to dig up dirt on Dave.
Lynette and Tom uncover the unsettling truth about son Porter. Gabrielle suspects Carlos' best client, Virginia, has ulterior motives. Bree's moment of weakness could bring her great embarrassment and shame. Katherine's not-so-little secret is unveiled. Susan learns of Jackson's true passion. Finally, Mrs. McCluskey's sister Roberta unearths a disturbing fact about Dave.
Susan's daughter Julie comes to visit with her surprising new boyfriend. Gabrielle learns that Mrs. Hildebrand has made her and Carlos heirs of her entire fortune. A reporter looks to expose Bree's imperfections. Lynette learns Porter and Anne Schilling plan to leave Fairview and disappear. Finally, everyone has gathered at a club to see the guys play in the annual "Battle of the Bands" when a fire erupts, threatening the lives of those in attendance. Some will fall as a hero will rise.
For Gaby and Carlos, injuries sustained in the fire lead to a fortunate discovery. But for most, the consequences are less forgiving. Lynette and Tom vow to protect son Porter at any cost. Susan must learn to let go of the man she loves. Orson's attempt at a good night's sleep puts Bree in a most precarious, though amusing, position on the day of her big cooking demonstration.
Lynette takes extreme measures to protect her son. Carlos realizes the extent of Gaby's sacrifices for their family. Bree wants to prove to Andrew that she has accepted him for who he is. Katherine finds happiness, as Susan and Mike recognize the fate of their relationship. Meanwhile, Dave starts to lose his grip.
Bree clashes with Alex's mother for their sons' affections. Gabrielle urges Carlos to take a six-figure job, even though it means spending more time away from home. Susan turns to Lee for company while Jackson is away. Lynette catches Preston talking to Porter on the phone. Meanwhile, Edie grows weary of Dave, whose strange behavior hasn't abated.
Susan and Edie accidentally lock themselves in a basement; the search for Porter leads Lynette to her mother; Mike and Katherine define their relationship; Dave gets closer to exacting revenge.
When Eli Scruggs (Beau Bridges), the neighborhood handyman, passes away, the residents of Wisteria Lane realize how much he affected their lives.
Bree treats herself to a new car; Susan wants to send M.J. to the best school even though she and Mike can't afford it; Gaby tries to get back into shape; Lee wonders if he should tell Tom and Lynette some disturbing facts about Dave.
Susan gets a new job. Lynette tells Tom they need to sell Scavo's Pizzeria. Gaby discovers that Carlos' boss has a dirty little secret; Orson confronts Bree after discovering she has given Andrew a raise.
Bree tells Lynette she will help Tom find a job; Carlos' adulterous boss puts Gaby in a precarious situation; after a chance encounter with an old acquaintance, Edie looks into Dave's past.
Susan tries to impress a teacher at work, Gaby talks Carlos into hiring Lynette, Edie continues to look into Dave's past.
Bree contemplates selling her business in order to revive her marriage. Meanwhile, Lynette is threatened at work; Katherine is caught in an unforseen circumstance; and Edie's worst fear begins to come true.
Edie becomes the subject as the other housewives reminisce about her: with Susan recalling the first time they met; Lynnette remembers an unforgettable night; Gaby remembers an evening of friendly competition; and Bree remembers how thoughtful she was towards Orson.
Carlos finds Lynette in a precarious position, which she chooses to hide from Tom, and Gabrielle hastily covers for Tom's coy behavior. Orson tries to hide the truth about his wounds from Bree, while Katherine confesses to Mike, which leads to a surprising realization. In the meantime, Susan confides her dark secret in Dave.
Bree sinks to a new low to retain the best lawyer, and Gabrielle's vanity is put to the test when she makes a deal with her daughter Juanita. Meanwhile, Lynette and Tom negotiate sex, and Katherine deceives Mike to win his heart. Jackson (guest star Gale Harold) walks back into Susan's life with a proposal, and an unexpected visit sends Dave to do some bargaining of his own.
Bree goes to extremes to hide her true intentions from Orson, while Susan and Jackson put on an act for the authorities. Lynette is shocked at the lengths Tom will go to in order to look younger, and Katherine masks the truth from Mike, afraid to lose him. Meanwhile, Dave is on edge when he learns a key witness to his misdeeds surfaces.
Gabrielle runs into an old acquaintance who's lost everything, Lynette is upset with Tom for his latest "bright idea," Orson threatens to blackmail Bree, and Susan accepts Dave's "friendly" gesture.
Lynette adapts to Tom's decision to go back to school, Orson takes a beating that Bree cannot comprehend, Gabrielle's niece moves to Wisteria Lane, and Susan and MJ's lives are in grave danger at the hands of Dave.
Paul Young, now out of prison, returns to Wisteria Lane with an enigmatic new wife; Susan, Mike and M.J. live in an apartment on limited funds; Lynette's successful college friends pays the Scavos an unexpected visit.
Lynette is angry when Renee starts spending a lot of time with Tom; Bree finds herself falling for Keith (Brian Austin Green); Susan feels guilty about her side job.
Susan is less than pleased when she finds out that some of her best and sexiest internet show moves are being copied by a competitor (guest star Rebecca Creskoff), and Gabrielle hires a private detective to look into an important matter, unbeknownst to Carlos. Meanwhile, Lynette is stunned when Tom's doctor prescribes him a rather unorthodox remedy for his depression, and Renee invites a reluctant Bree to go clubbing with her in order to engage in some local man-hunting.
Susan is horrified when she discovers that she has become the face of the provocative internet company she's been secretly working for and is now the cover model for their outdoor billboard ads; Gabrielle tells her coveted secret to the ladies; Renee finds out that Bree is a grandmother and uses it to her advantage in an attempt to steal Keith away and have him for herself; Lynette takes advantage of daughter Penny's generous offer to help look after the baby; and Paul purchases the home he shared with Mary Alice, against wife Beth's wishes.
Susan's days as a sexy internet sensation may be coming to an end after she angers an important client and incurs the wrath of her boss, Maxine; Renee and Gabrielle are headed for a smackdown after each of them reveals an intimate secret about the other to the wrong people; Bree finds herself exhausted by younger lover Keith's sexual stamina; Lynette is angry with Tom after he asks his mother to become the baby's nanny without talking it over with her first; and housewife Emma Graham puts on a cabaret show -- with the aid of saxophonist Dave Koz -- with surprising results.
Susan is forced to reveal her secret to Mike; Juanita becomes suspicious of Gaby's interest in Grace; Lynette is worried about Tom's mother's memory lapses; Bree learns a secret about Keith; and Paul takes Beth out on a date.
A reluctant Susan accepts Lynette's offer to be baby Paige's nanny; Bree meets Keith's parents; Renee makes a proposal that Lynette can't refuse; Gaby fears that Bob might be trying to seduce Carlos after they become friends; and Beth begins to question Paul's motives for returning to Wisteria Lane.
Thanksgiving on Wisteria Lane finds Gabrielle and Carlos hosting Carmen, Hector and Grace to a bountiful feast. But the Solis's discover some surprising news about the Sanchez's that could threaten their time with Grace. Meanwhile, Bree invites Keith's parents to partake in Thanksgiving at her house and learns some family secrets; Susan butts heads with Lynette over her sleep training techniques for baby Paige; Renee continues to remind Tom about their past; and Beth tries to uncover more about Paul's past misdeeds.
Gabrielle desperately tries to figure out a way to keep Grace in her life; Keith plans a very special dinner with Bree; Tom is angry at Lynette for not disclosing his special attributes to the other ladies; Renee tells Susan a deep, dark secret; and Paul's plan for Wisteria Lane is revealed
Paul's nefarious plan for Wisteria Lane is put into full effect. Juanita discovers that she isn't Gabrielle's biological daughter, and Bree invites Keith (guest star Brian Austin Green) to move in with her, whilst Tom is confronted about his past indiscretion with Renee.
Paul finds out that Beth is Felicia Tilman's daughter while a therapist asks Carlos and Gabrielle to erase Grace from their lives. Susan finds out she needs to go to the hospital every 48 hours and Renee finally tells the secret between her and Tom to Lynette. Orson returns and Bree gets torn apart with her feelings between Orson and Keith and detectives try to find the person responsible for shooting Paul Young.
Susan's mother and aunt visit her at the hospital, Lynette plots revenge against Tom, Gabrielle becomes increasingly obsessed with getting Grace back and Bree wants to be friends with Beth.
Lynette feels her mother is marrying Frank, an abrasive and obnoxious man, for all the wrong reasons, and thus tries to talk her out of it. Meanwhile, Carlos becomes concerned when he learns about Gabrielle's obsession with her doll, and Bob and Lee hire a non-maternal Renee to decorate their newly adopted girl's bedroom. Bree runs into Keith's ex-girlfriend and learns some shocking news about his past, and Susan tries to befriend a curmudgeonly man who has given up on ever finding a kidney donor. In the meantime, Paul appears to have some plans for Beth, as he books a trip for the two of them to a remote cabin in the woods.
While in therapy, Gabrielle learns the truth about her past; Keith becomes suspicious about Bree's secret; Lynette's mother tells a lie to a coroner about Frank's death; Mike confronts Zach about Paul's shooting; someone makes arrangements to give Susan a new kidney.
Gabrielle and Carlos head to Texas to visit Gabrielle's stepfather's grave; Lynette prohibits Porter and Preston from bringing home girls; Renee tries to use Susan's dialysis to help her get into a restaurant, but fails.
Susan vows to get the most out of life when she learns that her dialysis isn't working and that, unless she receives a kidney transplant soon, she will die. Meanwhile, jealous of Lee and Bob's adopted daughter's routine for an upcoming school talent show, Gaby pressures Juanita to come up with a number that will outshine everyone; Bree makes it her mission to find a kidney donor for Susan; Lynette puts a plan into action to discourage a clearly non-maternal Renee from adopting a baby; and Beth Young struggles to figure out what to do with her life after Paul kicks her out of the house.
Paul tries to stand between Susan and her kidney transplant; Felicia is released from prison and swears revenge against Paul; Gabrielle is furious about a neighborhood party planned by Renee; Tom is caught between working with Carlos and a job opportunity; Andrew's drinking concerns Bree.
Believing she's on a winning streak after undergoing a successful kidney transplant, Susan begins to think she's invincible and starts to gamble with the little money she and Mike have, convinced she can't lose. Meanwhile, Bree desperately tries to stop Andrew from admitting to Carlos that he was the one who accidentally killed his mother years ago, and Renee helps introduce Lynette to the world of high class, frivolous shopping now that Tom's bringing in the big bucks with his new, high-powered job. Felicia moves back into the neighborhood and tries to convince an extremely suspicious Paul that she wants to bury the hatchet and try to be civil to one another.
Gaby covertly meets Bree when Carlos forbids them from being friends after learning the truth about his mother's death. Meanwhile, saved by the late Beth Young's kidney donation, Susan begins to have some inappropriate dreams about Paul; Lynette is reluctant to be the "plus one" when she accompanies Tom to a weekend conference featuring the nation's top executives; and Felicia tries to regain Mrs. McCluskey's trust in her campaign to bring down Paul Young.
With Gaby and the girls temporarily staying at Bree's house, Bree must lay down the law and demand discipline before Juanita and Celia destroy her home. Meanwhile Tom hires Lynette and Renee to redecorate his office - but Lynette has her own ideas of what she thinks Tom needs as opposed to wants; and while continuing to help nurse Paul back to health, Susan discovers that Felicia has been released from prison and is back on Wisteria Lane.
Paul begins to suspect that Susan is responsible for his rapidly declining health; Lynette and Tom butt heads over where to go on their family vacation, as well as which one of them will set it up; Gaby shows Juanita a horror movie and has to pay the price when her daughter becomes too scared to sleep in her own bed; and Bree runs into some trust issues when she goes out on a date with a detective.
Gaby is stunned to learn the identity of the mysterious man who has been stalking her; Lynette and Tom attempt to put the spark back into their marriage by spending a few days alone together at a romantic Bed & Breakfast; after being placed under arrest for allegedly poisoning Paul, Susan must convince the police that she was being framed for the deed by Felicia; Bree begins to suspect that her new boyfriend may be gay.
Carlos and Gaby learn the truth about their baby. An ex-stripper gives birth to her child, and Gabrielle holds her for the first time. Also, Paul Young comes to face his demons head on with Wisteria Lane. Lastly, Lynette is forced to give a court deposition about Bree's drinking and alcoholism.
Gabrielle and Carlos are shocked when the father of their baby shows up to take the baby back. Cops and a lawyer arrive to a house on Wisteria Lane. Lynette tries to help Ed heat up his sex life. Meanwhile, Karl decides to break up with Edie, as Edie has no idea that Susan is the "other woman." Edie causes a fight to break out in a bar, after she trips a waitress. Lastly, Bree is taken a step forward to help Peter when she finds out how bad his other addiction is.
The neighborhood is shocked when news about Edie's suicide attempt spreads though Fairview. Lynette battles with the effects of chemotherapy. After a decade of absence, Katherine Mayfair moves back to Wisteria Lane with her new husband and daughter in her late teens.
Lynette kicks Tom out of her chemotherapy sessions. Susan is mistaken for a stripper. Bree attempts to steal a prize-winning recipe from Katherine.
Bree informs the housewives of what she overheard in the Mayfair house. Stella makes some special brownies to help Lynette through chemotherapy. Susan throws a charades party for the whole neighborhood.
Edie is shocked when she receives some news at the gynecologist's office. At the baby shower Bree's friends throw her, Bree's ex-mother-in-law Phyllis discovers her pregnancy is a hoax. Finally, Wisteria Lane welcomes to the street a homosexual couple.
Bob & Lee's contemporary water sculpture in their front yard prompts the Wisteria Lane neighborhood association into action. Edie finds out about the affair that Carlos is having with Gaby. Also, John Rowland wants to rekindle his romance with Gaby.
This is the show's first Halloween episode. Edie Britt's biggest fear comes true when Carlos walks out on their relationship. Susan finds Mike's father, who was supposedly dead. Danielle goes into labor right in the middle of the Halloween party... and somebody has to deliver the baby.
Lynette's sisters Lydia and Lucy come to visit. While having dinner with Susan and Mike, Bree and Orson realize they share different views on whether their newborn baby should be circumcised. On a boat, Victor confronts Gaby about her affair with Carlos and she throws him into the ocean. Later, Bree informs Susan that she thinks Mike is addicted to drugs.
A mysterious stalker from Adam's past shows up on Wisteria Lane, and they have dinner. Detectives question Gabrielle about Victor's whereabouts. Danielle's baby puts stress on Bree and Orson's marriage. Lynette has a reunion with her long-lost stepfather, Glen. Susan notices Mike is behaving strangely.
A tornado comes to Wisteria Lane, forcing residents into basements, cellars and safe rooms, and destroying homes and lives. Meanwhile, Susan ends up at the hospital after falling down the stairs.
In the aftermath of the tornado, the residents of Wisteria Lane try to rebuild their lives. Katherine discovers someone may know her secret while Lynette faces the possibility of her family's fate.
Two weeks after the tornado, with Mike still in rehab, Mrs. Delfino gets a visit from her cousin Tim. Meanwhile, Bree desperately awaits to return to her own house. Gabrielle learns that Carlos' blindness is permanent. Katherine is unable to keep some of her secrets from the women of Wisteria Lane. Finally, a surprise wedding ceremony has its own share of secrets.
Gabrielle struggles with the reality of having a blind husband. Lynette is surprised when Rick Coletti shows up at the Scavo pizzeria. Bree and Katherine join forces to plan the Founders Day Ball. As part of his recovery, Mike asks a few people for forgiveness, and Orson starts sleepwalking.
Bree and Katherine decide to start a catering business together. Lynette tries to deny her feelings for Rick. Mike learns the truth about his nearly fatal accident. Carlos gets a seeing-eye dog. Dylan meets her estranged father.
Susan meets her ex-husband, Karl at a Lamaze class, and finds out that he has remarried and is having another child. Lynette learns who was responsible for starting the fire at Rick's restaurant. Bree wants Orson to turn himself in to the police. Meanwhile, Gabrielle rents a room to a hip artist, Ellie, who has a dark secret. Elsewhere, Dylan continues meeting with her father, Wayne, and Katherine decides to go spy on her.
Adele Delfino, Susan's mother-in-law, arrives for a visit. Carlos and Gabrielle find out their tenant, Elli, has a dark secret. A full scale war erupts between Bree and Edie.
Susan and Mike try to name their son. Lynette is arrested for supposedly attacking Kayla, and Tom must do what he can to save his family. Bree is being stalked by Orson, and when she meets with Reverend Green, the reverend tries to hit on her. In the meantime, Gabrielle is still helping the police trying to detain Ellie for dealing drugs. Finally, Katherine is visited by her ex-husband, Wayne.
It is raining on Wisteria Lane, six months after Mike was run over. He is now in a coma, with Susan by his side. Bree gets engaged to Orson. Gabrielle and Carlos are getting divorced, but they are briefly reunited when their 8½ months pregnant surrogate Xiao-Mei runs away. While adjusting to having another child around the house, Lynette realizes that the girl's mother, Nora, is more than she can handle.
It's wedding day for Bree and Orson but things don't go quite as planned. Meanwhile, the body of a dead woman believed to be Orson's ex-wife is recovered, which interrupts the reception. Susan goes on a date with Ian, but trouble ensues when his in-laws show up at the restaurant. When Nora breaks up with her boyfriend, Lynette decide to hook up Nora with someone. Edie lets her 18-year-old nephew Austin come live with her for some time. Lastly, Xiao-Mei goes into labor.
It is a holiday weekend on Wisteria Lane. Bree and Orson are going on their honeymoon, while Gabrielle and Lynette are going a spa vacation and Tom is going on a camping trip with the kids. Meanwhile Susan is going on a quiet romantic getaway with Ian, not sure if she's cheating on Mike. However, things don't go as planned.
Mike has woken up from his coma, and has no recollection of the past two years, and Edie is there to fill in the blanks. Susan is still in the country with Ian, when she receives the news. Bree finds her family is anything but perfect. Lynette is determined not to let Parker quit baseball because he made a commitment, even though he's terrible at it. Carlos moves back into the Solis house, much to Gabrielle's displeasure.
The divorce between Gabrielle and Carlos reaches new levels of bitterness. Susan is determined to jog Mike's memory, and realizes Edie has been posing as his girlfriend since he woke up. Tom decides that his dream is to open a pizza parlor, and Lynette is not delighted. Bree tries to break up Danielle and her history teacher, who's been having an affair with her. Meanwhile, Mike's phone number is discovered on a dead woman's body.
Susan professes her love for Ian. Gabrielle and Carlos try to rekindle their love. Bree is confronted with Orson's past. In the meantime, Nora and Lynette go to war.
Lynette returns home from the hospital. Gabrielle decides to get back into modeling and travels to New York. Susan comes home to find Austin and Julie making out on her couch. Bree meets her antagonistic mother-in-law Gloria, with whom Orson is in a quarrel. Detective Ridley has Mike's house searched.
Gabrielle takes a shot at training potential young beauty queens. After discovering a wall of photos of half-naked boys in his basement, Lynette is convinced her new neighbor Art is a pedophile. Susan stays at Ian's house and clashes with his butler. Carlos asks Mike if he could stay with him for a while. With his mother living in the Hodge house temporarily, another part of Orson's past is revealed.
The residents of Wisteria Lane celebrate their annual holiday block party. Meanwhile, Gabrielle sets her eyes on a father of a girl she's coaching. Mike is arrested for Monique's murder. Thanks to Lynette, mothers of the neighborhood arrange a protest against Art. This causes his sister a heart attack. And Susan has to cook dinner for Ian's parents.
Tom and Lynette try to make Kayla feel like a part of the family. Alma Hodge decides to pay Orson and Bree a visit. Susan visits Mike in jail to tell him about the lawyer Ian got him. Gabrielle accuses Carlos of trying to sabotage her relationship with Bill. Bree organizes a dinner party to show Susan that Alma is alive.
Bree isn't happy Alma has moved to Wisteria Lane. Gabrielle's secret admirer is revealed. The new Scavo Pizzeria faces an uncertain future. Julie and Austin go to Edie about giving them parental consent to buy birth control pills.
Gabrielle cannot avoid Zach. Mike's new lawyer suggests he pleads guilty, but Susan doesn't agree with that. Gloria informs Bree that she and Alma believe Bree is the other woman. Instead of going back to work Lynette pretends to be ill so she can help Tom promote the pizzeria at a food fair.
Ian proposes to Susan. The Scavo pizzeria prepares for its grand opening. Mike visits a hypnotherapist in hopes of remembering Monique. Gabrielle's romantically interested in a lawyer, but he's working for Zach who wants her for himself. Bree is hospitalized after a fall, after being tricked to climb on a ladder to retrieve Monique's teeth.
All of Wisteria Lane gathers at Pizzeria Scavo for the grand opening event, while one resident meets an untimely fate and another accepts a marriage proposal.
Edie gets an unexpected visit from her son. An unexpected pregnancy causes complications. Victor Lang, a man in his 40s running for mayor of Fairview, introduces himself for Gabrielle. The deceased Rex Van De Kamp narrates.
Susan meets her in-laws and finds out some family. Victor is still taking his chances with Gabrielle, while she has a devastating catastrophe at her home. Lynette is encountering new problems at the pizzeria while an unexpected relationship develops on Wisteria Lane.
Susan considers moving from Wisteria Lane to London. Later, an accident causes Ian, Susan, and their car to find themselves stranded in a lake. Tom feels threatened by the interest a new Scavo's Pizzeria employee Rick shows in Lynette. While debating his opponent in the mayoral election, Victor Lang witnesses something disturbing.
Gabrielle and Victor will make an unexpected twist in their relationship and will also face a crisis as a video of them sharing a passionate moment in an elevator was caught on tape and is now being used to blackmail them. Edie gets into a fight with one of the ladies that will ruin their "friendship" while another lady on Wisteria Lane ends up in the hospital.
Susan goes to the therapist and realizes she must choose between Ian and Mike. Travers is having a birthday party which only spells trouble for Mrs. McCluskey, Gabrielle's engagement party is upstaged by an unexpected announcement and the neighborhood is full of gossip about the dead body found on Wisteria Lane.
Susan goes into the woods to try to find Mike. Gabrielle gets into an argument with a meter man who gives her a ticket. Victor is elected mayor, and Gabrielle goes back to teach the meter man a lesson. Edie's ex-husband comes back to collect Travers. Lynette realizes she has feelings for another man.
While Tom tries to save his marriage, Mike and Susan get engaged. However, Susan's happiness is short-lived when she realizes Gabrielle has stolen her cancelled wedding with Ian. Meanwhile, Edie wants Carlos to move in with her, and she's ready to do anything to make it happen.
As Gabrielle prepares for her fairy tale wedding, Bree returns to Fairview with a surprise. Meanwhile, Lynette's mother Stella pays her a visit after finding out Lynette has cancer. Finally, Susan and Mike tie the knot in an unexpected location.
Mike gets married and his bride is finally revealed will it be Katherine or Susan? Meanwhile, Lynette deals with the realities of being pregnant again; Bree works to break free from Orson; Gaby is tested by Carlos' niece who continues to stay with them; and a new family with dark secrets moves to Wisteria.
Mrs. McCluskey falls for a steak salesman called Roy Handler. Julie is found unconscious in the park bushes, which questions Mrs. McCluskey's decision to tell the police that she saw Angie Bolen's 19-year-old son, Danny, fighting with Julie.
A chance encounter reunites Gaby with her sexy ex-lover and gardener, John Rowland; Bree contemplates a weekend getaway with Karl; Lynette and Tom break the news to their kids that she's pregnant again; and Susan is convinced Angie's son is responsible for her daughter's attack.
Losing Mike takes its toll on Katherine. As Katherine unravels, Bree comes to her aid; Gaby grows weary of John’s intentions towards Ana with twins on the way, Lynette calls upon her family to step up around the house Susan learns Julie has been harboring some secrets and Angie throws a party for son, Danny.
When Juanita’s party is on the verge of being ruined after Gaby is deemed a bad mom, Gaby is determined to prove she’s a responsible parent. Bree gets defensive when she’s judged by a motel maid for having an affair with Karl. Lynette is put off by her new handyman when he defers to Tom for approval on all things and Susan and Katherine come to blows over Mike. Meanwhile, a lapse in judgment on Danny’s part leads to a terrible mishap that Angie and Nick must cover up.
Bree begins to fall for Karl and drifts further from Orson. Katherine continues her sad attempts at seducing Mike, as her conflict with Susan grows. Gaby gets Juanita expelled from school. Lynette learns Tom is cheating on his mid-term, and Angie hides the truth about her mother.
Susan believes that Katherine may be Julie's assailant. Angie invites reluctant Bree and Orson to dinner. Gaby struggles to home school Juanita. Lynette has her own suspicions about who attacked Julie. Angie confronts Nick.
Susan discovers a surprising connection between Mike and Katherine, which leads her to question her relationship with Mike. Meanwhile Gaby will stop at nothing to get Juanita into Catholic school, and Lynette's pregnancy becomes hysterically impossible to hide. Meanwhile, as Bree tries to hide her infidelity, Angie uncovers the truth about Orson and Bree's imperfect marriage.
In the wake of another attack, Angie decides the time has come for her and her family to leave Wisteria Lane; Bree and Susan are literally up in arms with one another as Bree's affair with Karl becomes increasingly difficult to hide; Lynette's pregnancy causes a rift with Gaby; and a confrontation between Mike and Katherine leads to a harmful and unexpected blow.
Gabrielle and Lynette's friendship is on the brink of collapse, whereas Bree and Orson come to an agreement about their marriage. Meanwhile, Susan hatches a plan to help an irrational Katherine, and Danny's vital mistake might cost Angie her freedom. In the meantime, Christmas cheer is curtailed when disaster strikes, as a plane crashes down on Wisteria Lane, putting lives in peril.
In the aftermath of the plane crash, the residents of Wisteria Lane think about what their lives might have been like had they made different choices. Susan contemplates a life with Karl had she not left him. Bree considers life without Orson. Lynette thinks about a future with her unborn twins. Carlos reflects on how Gaby would be as an over-protective mom and Angie ponders the consequences should her secrets be revealed.
Gaby and Angie challenge each other's parenting skills, Susan befriends a stripper and takes her under her wing, Lynette and Tom argue the merits of their new therapist, and a concerned Bree keeps a watchful eye on Orson for fear he may take his own life.
Former exotic dancer Robin will have a profound effect on Susan's friends with three teenage boys at home, Lynette will keep a watchful eye; Bree picks up a few tricks to engage Orson; Gaby looks for help with troublesome niece Ana; and Katherine will find a friendly companion.
Having never had the chicken pox herself, Gaby stays with Tuc and Bob and is reminded of what it's like to be single again; Lynette and Tom forget Penny's birthday; Bree hires a promising new employee; Susan cheats on Mrs. McKluskey; Katherine makes a surprising discovery and Angie grows concerned over Danny's disappearance.
While in the Big Apple, a chance encounter with supermodels Heidi Klum and Paulina Porizkova leads Gaby to an unexpected revelation about herself. Meanwhile, Lynette and Tom are in for a big surprise when Preston returns from Europe; Mike is determined to show Susan what a man he is after feeling emasculated; Bree discovers a shocking connection to her new employee, Sam; and Katherine is confused over her feelings for Robin.
Angie’s ex-boyfriend, Patrick, emerges after her trip to New York. Meanwhile it’s game on between Gaby and Susan, as they go to shameless lengths to top each other’s kids; Lynette believes there’s more to Preston’s fiancée than she’s letting on; Bree invites Sam over for a family dinner; and Katherine comes out of the closet.
Determined to derail son Preston's marriage to Irina, Lynette discovers the truth about her future daughter-in-law. In the meantime, Gabrielle offers to help out Bob and Lee in the most generous way, but does not consider the consequences. Bree begins to question whether Sam has a hidden agenda, and Susan gets creative to help Mike with his finances. Unbeknownst to Angie, Danny meets Patrick Logan for the very first time.
The Fairview strangler has been living among the women of Wisteria Lane. He once caught Gabrielle and Carlos in an intimate moment. Bree offered him a job and some dating advice. Susan encouraged his passion for art. Lynette will show him kindness and generosity. But... who is he?
Angie comes face to face with her ex, Patrick Logan, after years on the run. Meanwhile, Gaby and Susan plan an elaborate scheme against their husbands, Lynette sees a darker side of Eddie, and Bree meets a woman who knows Sam all too well.
Lynette comes to a shocking realization about Eddie. Meanwhile, Angie discreetly relies on Gaby for help when Patrick threatens the life of her son; Bree offers Sam a generous payoff to walk away; and Susan and Mike's financial woes result in the ultimate sacrifice.
Gaby risks her safety to help Angie; Lynette's fate and that of her unborn child lie in the hands of Eddie; Susan comes to grips with her financial woes; Bree considers confessing a secret she's harbored for years; and Angie must submit to Patrick's demands in order to protect her son.