Three sisters (Prue, Piper and Phoebe) reunite and unlock their powers to become the Charmed Ones, the most powerful witches to exist. Now they must vanquish evil and save innocents while living their lives as normal women in the real world. Life isn't so easy when you're Charmed.
Phoebe returns to San Francisco after losing her job to live with her older sisters, Prue and Piper. During their first night together in their grandmother's house, Phoebe finds a book of witchcraft and recites an incantation that leaves the sisters three with powers they were destined to have.
Piper has trouble dealing with her powers and fears what might happen if she enters a church. Meanwhile, Phoebe meets a photographer who sucks the life out of young women to keep himself young, and Prue faces relationship complications with Andy when she gets a job at an auction house.
The sisters' estranged father returns, but he trouble arises when he teams up with the new neighbors, who are actually shape-shifters trying to steal the Book of Shadows. Meanwhile, a handyman comes to the manor to help the girls.
Piper falls for the ghost of a recently murdered man who needs her help. Meanwhile, Phoebe works as a psychic to help others and make money for Prue's birthday present, and Prue discovers a devastating betrayal.
Prue finds her sleep disturbed by strange visions in which she's taunted by a man. Meanwhile Phoebe and Piper cast a spell to attract men, but it turns out too strong, and they can barely escape their myriad of admirers.
A troubled teenage girl befriends Phoebe with the hopes of joining the Halliwells, but she's been lured to the dark powers of witchcraft by a sorceress. Meanwhile, Prue tries to find time with Andy and Phoebe and Piper vie for the attention of Leo.
Acting on Phoebe's premonitions, the sisters race to stop a mysterious killer from striking again. Meanwhile, Prue finds a truth spell and uses it to find out what Andy's reaction to her being a witch would be.
A warlock from the past is released from his curse and tries to steal the sisters' powers with the help of Rex and Hannah, but the sisters resurrect their ancestor to combat him. Meanwhile, Piper works up her courage to ask Leo out and Andy gets frustrated by Prue's continued involvement with bizarre police investigations.